|
Symbol Name ID |
Grn
granulin MGI:95832 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Dysphagia |
Spasticity |
Fatigable weakness of bulbar muscles |
Fatigable weakness of swallowing muscles |
Fatigable weakness of respiratory muscles |
Gliosis |
Motor neuron atrophy |
Amyotrophic lateral sclerosis |
Lateral ventricle dilatation |
Cerebral cortical atrophy |
Lewy bodies |
Neurofibrillary tangles |
Cerebellar atrophy |
Neurodegeneration |
Neuronal loss in central nervous system |
Ataxia |
Parkinsonism |
Apraxia |
Fasciculations |
Paralysis |
Babinski sign |
EEG with generalized polyspikes |
Aphasia |
Dysarthria |
Mutism |
Language impairment |
Depression |
Emotional lability |
Irritability |
Anxiety |
Hallucinations |
Perseverative thought |
Atypical behavior |
Diminished motivation |
Apathy |
Abnormal sexual behavior |
Hypersexuality |
Inappropriate laughter |
Personality changes |
Polyphagia |
Disinhibition |
Agitation |
Repetitive compulsive behavior |
Hyperorality |
Cognitive impairment |
Memory impairment |
Mental deterioration |
Dementia |
Frontal lobe dementia |
Frontotemporal dementia |
Progressive language deterioration |
Sleep abnormality |
Hyperreflexia |
Jaw hyperreflexia |
Primitive reflex |
Seizure |
Generalized myoclonic seizure |
| Disease(s) Associated with GRN | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| amyotrophic lateral sclerosis | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| frontotemporal dementia | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Grn-related frontotemporal lobar degeneration with Tdp43 inclusions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| neuronal ceroid lipofuscinosis 11 |
| Mouse Phenotypes | nervous system phenotype |
increased susceptibility to dopaminergic neuron neurotoxicity |
microgliosis |
abnormal microglial cell physiology |
abnormal brain morphology |
decreased brain weight |
abnormal midbrain morphology |
abnormal hypothalamus morphology |
abnormal paraventricular hypothalamic nucleus morphology |
abnormal supraoptic nucleus morphology |
abnormal thalamus morphology |
abnormal thalamus neuron morphology |
abnormal retrosplenial region morphology |
abnormal hippocampus morphology |
abnormal cerebral cortex morphology |
abnormal primary motor cortex morphology |
abnormal frontal lobe morphology |
tau protein deposits |
astrocytosis |
loss of dopaminergic neurons |
abnormal neurite morphology |
abnormal dendrite morphology |
decreased dendritic spine density |
abnormal retina ganglion cell morphology |
retina ganglion cell degeneration |
abnormal synapse morphology |
neuronal cytoplasmic inclusions |
nervous system inclusion bodies |
neurodegeneration |
abnormal nervous system physiology |
abnormal hypothalamus secretion |
abnormal neuron physiology |
impaired synaptic plasticity |
abnormal excitatory postsynaptic potential |
reduced long-term potentiation |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||
| Grntm1.1Aidi/Grntm1.1Aidi | ||||||||||||||||||||||||||||||||||||
| Grntm1.1Far/Grntm1.1Far | ||||||||||||||||||||||||||||||||||||
| Grntm1.1Geno/Grntm1.1Geno | ||||||||||||||||||||||||||||||||||||
| Grntm1Blrl/Grntm1Blrl | * | |||||||||||||||||||||||||||||||||||
| Grntm2.1Far/Grntm2.1Far | ||||||||||||||||||||||||||||||||||||
| Grntm1.1Hiok/Grn+ | ||||||||||||||||||||||||||||||||||||
| Grntm1Far/Grntm1Far Tg(ITGAM-cre)2781Gkl/0 (conditional) |
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| Grntm1Far/Grntm1Far (conditional) | ||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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